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Science 25 February 2005:
Vol. 307. no. 5713, pp. 1211 - 1212
DOI: 10.1126/science.1109836
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Perspectives

MICROBIOLOGY:
A Pathogen Attacks While Keeping Up Defense

Staffan Normark, Christina Nilsson, Birgitta Henriques Normark

Certain species of Shigella and Yersinia bacteria are serious human pathogens. In a Perspective, Normark and colleagues discuss two exciting studies (West et al., Mota et al.) that shed light on the mechanisms enabling Shigella and Yersinia to invade host target cells. The new work may pave the way to designing new therapeutics to block invasion of host cells by these human pathogens.

The authors are at the Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, 171 77, Sweden. E-mail: staffan.normark{at}stratresearch.se

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