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Mammalian SAD Kinases Are Required for Neuronal Polarization
Masashi Kishi,1*Y. Albert Pan,1,2*Justin Gage Crump,3Joshua R. Sanes1,2
Electrical activity in neurons is generally initiated in dendriticprocesses then propagated along axons to synapses, where itis passed to other neurons. Major structural features of neurons—theirdendrites and axons—are thus related to their fundamentalfunctions: the receipt and transmission of information. Theacquisition of these distinct properties by dendrites and axons,called polarization, is a critical step in neuronal differentiation.We show here that SAD-A and SAD-B, mammalian orthologs of akinase needed for presynaptic differentiation in Caenorhabditiselegans, are required for neuronal polarization. These kinaseswill provide entry points for unraveling signaling mechanismsthat polarize neurons.
1 Department of Anatomy and Neurobiology, Washington University Medical School, St. Louis, MO 63110, USA. 2 Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. 3 Department of Anatomy, University of California, San Francisco, CA 94143, USA.
* These authors contributed equally to this work.
Present address: Institute of Neuroscience, University of Oregon,Eugene, OR 97403, USA.
To whom correspondence should be addressed. E-mail: sanesj{at}mcb.harvard.edu
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Present address: Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA. 
To whom correspondence should be addressed. E-mail: 
