Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Originally published in Science Express on 9 December 2004
Science 11 February 2005:
Vol. 307. no. 5711, pp. 925 - 928
DOI: 10.1126/science.1103978
Prev | Table of Contents | Next

Reports

Lymphotoxin-Mediated Regulation of {gamma}{delta} Cell Differentiation by {alpha}ß T Cell Progenitors

Bruno Silva-Santos,* Daniel J. Pennington,*{dagger} Adrian C. Hayday{dagger}

The thymus gives rise to two T cell lineages, {alpha}ß and {gamma}{delta}, that are thought to develop independently of one another. Hence, double positive (DP) thymocytes expressing CD4 and CD8 coreceptors are usually viewed simply as progenitors of CD4+ and CD8+ {alpha}ß T cells. Instead we report that DP cells regulate the differentiation of early thymocyte progenitors and {gamma}{delta} cells, by a mechanism dependent on the transcription factor RORgt, and the lymphotoxin (LT) ß receptor (LTßR). This finding provokes a revised view of the thymus, in which lymphoid tissue induction-type processes coordinate the developmental and functional integration of the two T cell lineages.

Peter Gorer Department of Immunobiology, Guy's King's St. Thomas' Medical School, King's College, Guy's Hospital, London SE1 9RT, UK.

* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. E-mail: daniel.pennington{at}kcl.ac.uk (D.J.P.), adrian.hayday{at}kcl.ac.uk (A.C.H.)

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and {gamma}{delta} T cells in vivo.
J.-s. Do and B. Min (2009)
Blood 113, 6361-6371
   Abstract »    Full Text »    PDF »
Cooperation between Molecular Targets of Costimulation in Promoting T Cell Persistence and Tumor Regression.
B. Zhao, A. Song, R. Haque, F. Lei, L. Weiler, X. Xiong, Y. Wu, M. Croft, and J. Song (2009)
J. Immunol. 182, 6744-6752
   Abstract »    Full Text »    PDF »
Id3 Restricts the Developmental Potential of {gamma}{delta} Lineage during Thymopoiesis.
I. Ueda-Hayakawa, J. Mahlios, and Y. Zhuang (2009)
J. Immunol. 182, 5306-5316
   Abstract »    Full Text »    PDF »
Thymic OX40 Expression Discriminates Cells Undergoing Strong Responses to Selection Ligands.
M. Klinger, J. K. Kim, S. A. Chmura, A. Barczak, D. J. Erle, and N. Killeen (2009)
J. Immunol. 182, 4581-4589
   Abstract »    Full Text »    PDF »
Increased Regulatory versus Effector T Cell Development Is Associated with Thymus Atrophy in Mouse Models of Multiple Myeloma.
A. Laronne-Bar-On, D. Zipori, and N. Haran-Ghera (2008)
J. Immunol. 181, 3714-3724
   Abstract »    Full Text »    PDF »
Overexpression of Lymphotoxin in T Cells Induces Fulminant Thymic Involution.
M. Heikenwalder, M. Prinz, N. Zeller, K. S. Lang, T. Junt, S. Rossi, A. Tumanov, H. Schmidt, J. Priller, L. Flatz, et al. (2008)
Am. J. Pathol. 172, 1555-1570
   Abstract »    Full Text »    PDF »
Airway Hyperresponsiveness through Synergy of {gamma}{delta} T Cells and NKT Cells.
N. Jin, N. Miyahara, C. L. Roark, J. D. French, M. K. Aydintug, J. L. Matsuda, L. Gapin, R. L. O'Brien, E. W. Gelfand, and W. K. Born (2007)
J. Immunol. 179, 2961-2968
   Abstract »    Full Text »    PDF »
Interactions between epithelial cells and leukocytes in immunity and tissue homeostasis.
R. Shaykhiev and R. Bals (2007)
J. Leukoc. Biol. 82, 1-15
   Abstract »    Full Text »    PDF »
Regulation of {gamma}{delta} Versus {alpha}{beta} T Lymphocyte Differentiation by the Transcription Factor SOX13.
H. J. Melichar, K. Narayan, S. D. Der, Y. Hiraoka, N. Gardiol, G. Jeannet, W. Held, C. A. Chambers, and J. Kang (2007)
Science 315, 230-233
   Abstract »    Full Text »    PDF »
Regulatory T cell-mediated suppression: potential role of ICER.
J. Bodor, Z. Fehervari, B. Diamond, and S. Sakaguchi (2007)
J. Leukoc. Biol. 81, 161-167
   Abstract »    Full Text »    PDF »
Human {alpha}beta and {gamma}{delta} Thymocyte Development: TCR Gene Rearrangements, Intracellular TCRbeta Expression, and {gamma}{delta} Developmental Potential--Differences between Men and Mice.
M. L. Joachims, J. L. Chain, S. W. Hooker, C. J. Knott-Craig, and L. F. Thompson (2006)
J. Immunol. 176, 1543-1552
   Abstract »    Full Text »    PDF »
Many roads, one destination for T cell progenitors.
H. T. Petrie and P. W. Kincade (2005)
J. Exp. Med. 202, 11-13
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)