Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
ESF Genomics

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 11 February 2005:
Vol. 307. no. 5711, pp. 896 - 901
DOI: 10.1126/science.1103736
Prev | Table of Contents | Next

Research Articles

Optical Imaging of Neuronal Populations During Decision-Making

K. L. Briggman,1 H. D. I. Abarbanel,2,3 W. B. Kristan, Jr.1*

We investigated decision-making in the leech nervous system by stimulating identical sensory inputs that sometimes elicit crawling and other times swimming. Neuronal populations were monitored with voltage-sensitive dyes after each stimulus. By quantifying the discrimination time of each neuron, we found single neurons that discriminate before the two behaviors are evident. We used principal component analysis and linear discriminant analysis to find populations of neurons that discriminated earlier than any single neuron. The analysis highlighted the neuron cell 208. Hyperpolarizing cell 208 during a stimulus biases the leech to swim; depolarizing it biases the leech to crawl or to delay swimming.

1 Division of Biological Sciences, University of California–San Diego, La Jolla, CA 92093–0357, USA.
2 Department of Physics, University of California–San Diego, La Jolla, CA 92093–0357, USA.
3 Marine Physical Laboratory, Scripps Institution of Oceanography, La Jolla, CA 92093–0402, USA.

* To whom correspondence should be addressed. E-mail: wkristan{at}ucsd.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Physiology and Morphology of Shared and Specialized Spinal Interneurons for Locomotion and Scratching.
A. Berkowitz (2008)
J Neurophysiol 99, 2887-2901
   Abstract »    Full Text »    PDF »
Behavioral and neural responses of juvenile crayfish to moving shadows.
W. H. Liden and J. Herberholz (2008)
J. Exp. Biol. 211, 1355-1361
   Abstract »    Full Text »    PDF »
Currents Contributing to Decision Making in Neurons B31/B32 of Aplysia.
I. Hurwitz, A. Ophir, A. Korngreen, J. Koester, and A. J. Susswein (2008)
J Neurophysiol 99, 814-830
   Abstract »    Full Text »    PDF »
Mechanosensory Gating of Proprioceptor Input to Modulatory Projection Neurons.
M. P. Beenhakker, M. S. Kirby, and M. P. Nusbaum (2007)
J. Neurosci. 27, 14308-14316
   Abstract »    Full Text »    PDF »
Reflections on integrative and comparative movement neuroscience.
D. G. Stuart (2007)
Integr. Comp. Biol. 47, 482-504
   Abstract »    Full Text »    PDF »
"Nanosized Voltmeter" Enables Cellular-Wide Electric Field Mapping.
K. M. Tyner, R. Kopelman, and M. A. Philbert (2007)
Biophys. J. 93, 1163-1174
   Abstract »    Full Text »    PDF »
Modulation of locomotor activity in larval zebrafish during light adaptation.
H. A. Burgess and M. Granato (2007)
J. Exp. Biol. 210, 2526-2539
   Abstract »    Full Text »    PDF »
Neural Circuits Mediate Electrosensory Behavior in Caenorhabditis elegans.
C. V. Gabel, H. Gabel, D. Pavlichin, A. Kao, D. A. Clark, and A. D. T. Samuel (2007)
J. Neurosci. 27, 7586-7596
   Abstract »    Full Text »    PDF »
Spinal Interneurons That Are Selectively Activated during Fictive Flexion Reflex.
A. Berkowitz (2007)
J. Neurosci. 27, 4634-4641
   Abstract »    Full Text »    PDF »
Multiple Contributions of an Input-Representing Neuron to the Dynamics of the Aplysia Feeding Network.
A. Proekt, J. Jing, and K. R. Weiss (2007)
J Neurophysiol 97, 3046-3056
   Abstract »    Full Text »    PDF »
Metastability of Active CA3 Networks.
T. Sasaki, N. Matsuki, and Y. Ikegaya (2007)
J. Neurosci. 27, 517-528
   Abstract »    Full Text »    PDF »
Imaging dedicated and multifunctional neural circuits generating distinct behaviors..
K. L. Briggman and W. B. Kristan Jr (2006)
J. Neurosci. 26, 10925-10933
   Abstract »    Full Text »    PDF »
The structure of multi-neuron firing patterns in primate retina..
J. Shlens, G. D. Field, J. L. Gauthier, M. I. Grivich, D. Petrusca, A. Sher, A. M. Litke, and E. J. Chichilnisky (2006)
J. Neurosci. 26, 8254-8266
   Abstract »    Full Text »    PDF »
Beyond the central pattern generator: amine modulation of decision-making neural pathways descending from the brain of the medicinal leech.
K. M. Crisp and K. A. Mesce (2006)
J. Exp. Biol. 209, 1746-1756
   Abstract »    Full Text »    PDF »
Single Neurons Can Induce Phase Transitions of Cortical Recurrent Networks with Multiple Internal States.
S. Fujisawa, N. Matsuki, and Y. Ikegaya (2006)
Cereb Cortex 16, 639-654
   Abstract »    Full Text »    PDF »
Overcoming photodamage in second-harmonic generation microscopy: Real-time optical recording of neuronal action potentials.
L. Sacconi, D. A. Dombeck, and W. W. Webb (2006)
PNAS 103, 3124-3129
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)