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Science 4 February 2005:
Vol. 307. no. 5710, p. 641
DOI: 10.1126/science.307.5710.641n
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Understanding how genes function within an organism requires an evaluation of temporal as well as physical interactions. De Lichtenberg et al. (p. 721) have combined confidence-scored protein-protein interaction data with microarray data to provide a detailed view of cell cycle biology in yeast. The approach was used to make predictions about gene function. Almost all cell cycle complexes contained both subunits that showed a dynamic as well as those that had an unchanging pattern of expression. The dynamic subunits were the targets of cyclin-dependent phosphorylation and it was their expression that was associated with the time at which the complex functioned.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)