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Science 28 January 2005:
Vol. 307. no. 5709, pp. 528 - 530
DOI: 10.1126/science.1108598
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Perspectives

PARASITOLOGY:
Malaria Vaccines: Back to the Future?

A. P. Waters, M. M. Mota, M. R. van Dijk, C. J. Janse

The malaria parasite kills several million people each year, many of them young children in sub-Saharan Africa. A forty-year effort to develop either a subunit or attenuated whole-organism vaccine has met with little success. However, as Andy Waters and colleagues discuss in their Perspective, a new study in mice using genetically attenuated sporozoites of a rodent malaria parasite has yielded a promising protective response in vaccinated animals. The Perspective authors discuss the possibility of developing a human malaria vaccine based on this strategy.

A. P. Waters, M. R. van Dijk, and C. J. Janse are in the Department of Parasitology, Leiden University Medical Centre, Leiden 2300 RC, Netherlands. M. M. Mota is at the Instituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal. E-mail: a.p.waters {at}lumc.nl

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Developmental Biology of Sporozoite-Host Interactions in Plasmodium falciparum Malaria: Implications for Vaccine Design.
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