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Science 14 January 2005:
Vol. 307. no. 5707, pp. 217 - 218
DOI: 10.1126/science.1108164
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Perspectives

CELL SIGNALING:
Stat Acetylation--A Key Facet of Cytokine Signaling?

John J. O'Shea, Yuka Kanno, Xiaomin Chen, David E. Levy

Modification of proteins by addition of, for example, phosphate groups to particular amino acids in the protein is an important way to regulate the protein's activity. In their Perspective, O'Shea and colleagues discuss the intriguing finding that addition of an acetyl group to an amino acid in an important group of transcription factors called Stats might regulate their activity (Yuan et al.).

J. J. O'Shea and Y. Kanno are in the National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA. X. Chen is in the Department of Biochemistry and Molecular Biology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA. D. E. Levy is in the Departments of Pathology and Microbiology, New York University School of Medicine, New York, NY 10016, USA.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy.
M. Pang, J. Kothapally, H. Mao, E. Tolbert, M. Ponnusamy, Y. E. Chin, and S. Zhuang (2009)
Am J Physiol Renal Physiol 297, F996-F1005
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A phosphorylation-acetylation switch regulates STAT1 signaling.
O. H. Kramer, S. K. Knauer, G. Greiner, E. Jandt, S. Reichardt, K.-H. Guhrs, R. H. Stauber, F. D. Bohmer, and T. Heinzel (2009)
Genes & Dev. 23, 223-235
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Hyaluronan-Mediated Leukocyte Adhesion and Dextran Sulfate Sodium-Induced Colitis Are Attenuated in the Absence of Signal Transducer and Activator of Transcription 1.
S. K. Bandyopadhyay, C. A. de la Motte, S. P. Kessler, V. C. Hascall, D. R. Hill, and S. A. Strong (2008)
Am. J. Pathol. 173, 1361-1368
   Abstract »    Full Text »    PDF »


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