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Calcium ions are crucial second-messenger molecules and are particularly important during T cell development and activation. In their Perspective, Winslow and Crabtree discuss the identification of two ion channels that are key regulators of the calcium response during activation of T cells (Badou et al. and Launay et al.).
M. M. Winslow is in the Immunology Program and G. R. Crabtree is in the Departments of Pathology and Developmental Biology at the Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. E-mail: crabtree{at}stanford.edu
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