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Science 17 December 2004:
Vol. 306. no. 5704, pp. 2050 - 2051
DOI: 10.1126/science.1107069
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Perspectives

CELL BIOLOGY:
Oxygen Sensing: It's a Gas!

Toshinori Hoshi and Sukhamay Lahiri

Oxygen-sensing glomus cells in the carotid body of the carotid artery are responsible for detecting low oxygen levels and for inducing a compensatory increase in respiration rate. However, the molecular mechanism of oxygen sensing in these glomus cells has remained enigmatic. In their Perspective, Hoshi and Lahiri explore new work that identifies the oxygen sensor as a cooperative effort between hemoxygenase, the gas it produces (CO), and the BK channels of glomus cells, which respond to CO by remaining open (Williams et al.).

The authors are in the Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. E-mail: hoshi{at}hoshi.org; lahiri{at}mail.med.upenn.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Carotid body oxygen sensing.
J. Lopez-Barneo, P. Ortega-Saenz, R. Pardal, A. Pascual, and J. I. Piruat (2008)
Eur. Respir. J. 32, 1386-1398
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Heterogeneity of hypoxia-mediated decrease in IK(V) and increase in [Ca2+]cyt in pulmonary artery smooth muscle cells.
O. Platoshyn, Y. Yu, E. A Ko, C. V. Remillard, and J. X.-J. Yuan (2007)
Am J Physiol Lung Cell Mol Physiol 293, L402-L416
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Evidence That the Heme Regulatory Motifs in Heme Oxygenase-2 Serve as a Thiol/Disulfide Redox Switch Regulating Heme Binding.
L. Yi and S. W. Ragsdale (2007)
J. Biol. Chem. 282, 21056-21067
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Thromboxane hypersensitivity in hypoxic pulmonary artery myocytes: altered TP receptor localization and kinetics.
M. Hinton, A. Gutsol, and S. Dakshinamurti (2007)
Am J Physiol Lung Cell Mol Physiol 292, L654-L663
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The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology.
K. Bedard and K.-H. Krause (2007)
Physiol Rev 87, 245-313
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Acute Oxygen Sensing in Heme Oxygenase-2 Null Mice.
P. Ortega-Saenz, A. Pascual, R. Gomez-Diaz, and J. Lopez-Barneo (2006)
J. Gen. Physiol. 128, 405-411
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COUNTERPOINT: HYPOXIC PULMONARY VASOCONSTRICTION IS NOT MEDIATED BY INCREASED PRODUCTION OF REACTIVE OXYGEN SPECIES.
E. K. Weir and S. L. Archer (2006)
J Appl Physiol 101, 995-998
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Oxygen sensors in hypoxic pulmonary vasoconstriction.
N. Weissmann, N. Sommer, R. T. Schermuly, H. A. Ghofrani, W. Seeger, and F. Grimminger (2006)
Cardiovasc Res 71, 620-629
   Abstract »    Full Text »    PDF »


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