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IMMUNOLOGY: The Elusive NKT Cell Antigen--Is the Search Over?
Dale I. Godfrey, Daniel G. Pellicci, Mark J. Smyth
NKT cells of the immune system are crucial for suppressing autoimmunity and graft rejection, boosting resistance to infection, and promoting tumor immunity. However, little is known about the endogenous antigens that are recognized by these cells. In their Perspective, Godfrey et al. discuss new research that identifies the glycosphingolipid iGb3 as an antigen recognized by NKT cells that is necessary for their development and activation (Zhou et al.).
D. I. Godfrey and D. G. Pellicci are in the Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia. M. J. Smyth is in the Cancer Immunology Program, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia. E-mail: godfrey{at}unimelb.edu.au
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[DOI: 10.1126/science.1103440] |Abstract »|Full Text »|PDF »|Supporting Online Material »
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The Influence of CD1d in Postselection NKT Cell Maturation and Homeostasis.
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175, 3762-3768
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