Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 19 November 2004:
Vol. 306. no. 5700, pp. 1304 - 1305
DOI: 10.1126/science.1105528
Prev | Table of Contents | Next

Perspectives

STRUCTURAL BIOLOGY:
Voltage Sensor Meets Lipid Membrane

Roderick MacKinnon

Several crystal structures of the bacterial voltage-dependent K+ channel have provided intriguing insights into how voltage-dependent ion channels work. In his Perspective, MacKinnon provides a primer on how the voltage sensor of voltage-dependent K+ channels works, and updates the primer with new data provided by the latest spectroscopic study from Perozo's group.

The author is in the Howard Hughes Medical Institute and Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, NY 10021, USA. E-mail: mackinn{at}rockefeller.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Three-dimensional Reconstruction of a Membrane-bending Complex: THE RC-LH1-PufX CORE DIMER OF RHODOBACTER SPHAEROIDES.
P. Qian, P. A. Bullough, and C. N. Hunter (2008)
J. Biol. Chem. 283, 14002-14011
   Abstract »    Full Text »    PDF »
S-acylation regulates Kv1.5 channel surface expression.
L. Zhang, K. Foster, Q. Li, and J. R. Martens (2007)
Am J Physiol Cell Physiol 293, C152-C161
   Abstract »    Full Text »    PDF »
Size Matters: Erythromelalgia Mutation S241T in Nav1.7 Alters Channel Gating.
A. Lampert, S. D. Dib-Hajj, L. Tyrrell, and S. G. Waxman (2006)
J. Biol. Chem. 281, 36029-36035
   Abstract »    Full Text »    PDF »
Positioning of proteins in membranes: A computational approach..
A. L. Lomize, I. D. Pogozheva, M. A. Lomize, and H. I. Mosberg (2006)
Protein Sci. 15, 1318-1333
   Abstract »    Full Text »    PDF »
Voltage-Dependent Hydration and Conduction Properties of the Hydrophobic Pore of the Mechanosensitive Channel of Small Conductance.
S. A. Spronk, D. E. Elmore, and D. A. Dougherty (2006)
Biophys. J. 90, 3555-3569
   Abstract »    Full Text »    PDF »
Effects of {delta}-Conotoxins PVIA and SVIE on Sodium Channels in the Amphibian Sympathetic Nervous System.
P. J. West, G. Bulaj, and D. Yoshikami (2005)
J Neurophysiol 94, 3916-3924
   Abstract »    Full Text »    PDF »
Phosphatidylinositol 4,5-Bisphosphate Rescues TRPM4 Channels from Desensitization.
Z. Zhang, H. Okawa, Y. Wang, and E. R. Liman (2005)
J. Biol. Chem. 280, 39185-39192
   Abstract »    Full Text »    PDF »
Voltage Sensor of Kv1.2: Structural Basis of Electromechanical Coupling.
S. B. Long, E. B. Campbell, and R. MacKinnon (2005)
Science 309, 903-908
   Abstract »    Full Text »    PDF »
KvAP-Based Model of the Pore Region of Shaker Potassium Channel Is Consistent with Cadmium- and Ligand-Binding Experiments.
I. Bruhova and B. S. Zhorov (2005)
Biophys. J. 89, 1020-1029
   Abstract »    Full Text »    PDF »
How ion channels sense membrane potential.
R. Horn (2005)
PNAS 102, 4929-4930
   Full Text »    PDF »
Membrane Insertion of a Potassium-Channel Voltage Sensor.
T. Hessa, S. H. White, and G. von Heijne (2005)
Science 307, 1427
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)