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Science 19 November 2004:
Vol. 306. no. 5700, pp. 1301 - 1302
DOI: 10.1126/science.1100889
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Perspectives

MATERIALS SCIENCE:
Shaping Crystals with Biomolecules

James J. De Yoreo and Patricia M. Dove

The complex shapes of biominerals cannot be explained with simple mechanistic models of crystal growth. In their Perspective, De Yoreo and Dove, argue that the popular "stereochemical recognition" model, which postulates that some shapes are stabilized through the binding of peptides and proteins to otherwise unstable faces, is not the full answer, either. According to recent studies, specific interactions between growth modifiers such as proteins and the edges of individual steps on existing crystal faces change the elementary step change to generate a similarly modified bulk crystal shape. The emergence of new faces is a macroscopic manifestation of the kinetics caused by molecular-scale interactions at the step edges.

J. J. De Yoreo is in the Chemistry and Materials Science Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA. E-mail: deyoreo1{at}llnl.gov P. M. Dove is in the Department of Geosciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. E-mail: dove{at}vt.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)