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Science 19 November 2004:
Vol. 306. no. 5700, pp. 1299 - 1300
DOI: 10.1126/science.1100137
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Perspectives

MOLECULAR BIOLOGY:
Knives, Accomplices, and RNA

Marvin Wickens and Tania N. Gonzalez

There are many proteins known to cleave different types of RNAs, but it is not clear whether they all act separately or sometimes cooperate. In their Perspective, Wickens and Gonzalez discuss the search for the enzyme that cleaves pre-mRNAs to form the 3' end of mRNAs. They reveal the surprising finding that this enzyme colludes with the enzymes that cut pre-tRNAs.

The authors are in the Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA. E-mail: wickens{at}biochem.wisc.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The role of the putative 3' end processing endonuclease Ysh1p in mRNA and snoRNA synthesis.
M. Garas, B. Dichtl, and W. Keller (2008)
RNA 14, 2671-2684
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A novel endonuclease activity associated with the Arabidopsis ortholog of the 30-kDa subunit of cleavage and polyadenylation specificity factor.
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Nucleic Acids Res. 35, 4453-4463
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