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Science 19 November 2004:
Vol. 306. no. 5700, p. 1277
DOI: 10.1126/science.306.5700.1277
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News of the Week

MEDICINE:
Estrogen's Ties to COX-2 May Explain Heart Disease Gender Gap

Jennifer Couzin

Estrogen recruits the enzyme COX-2 in the blood vessels of mice, according to research published online by Science this week (www.sciencemag.org/cgi/content/abstract/1103333), raising the possibility that COX-2 inhibitors--including Vioxx, which was yanked off the market in September because of cardiovascular risks--might be particularly hazardous to females.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
CRHR1 Polymorphisms Predict Bone Density in Survivors of Acute Lymphoblastic Leukemia.
T. S. Jones, S. C. Kaste, W. Liu, C. Cheng, W. Yang, K. G. Tantisira, C.-H. Pui, and M. V. Relling (2008)
J. Clin. Oncol. 26, 3031-3037
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)