Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 12 November 2004:
Vol. 306. no. 5699, pp. 1138 - 1139
DOI: 10.1126/science.1105511
Prev | Table of Contents | Next

Policy Forum

MOLECULAR BIOLOGY:
NIH Molecular Libraries Initiative

Christopher P. Austin,1* Linda S. Brady,2 Thomas R. Insel,2 and Francis S. Collins1

The Molecular Libraries Initiative (MLI) of the NIH Roadmap for Medical Research is a bold set of programs to facilitate the use of small molecules in the public sector and expand the reach of small-molecule technologies to define gene, cell, and organism function in health and disease. The initiative described in this Policy Forum has three components: the Molecular Libraries Screening Centers Network; cheminformatics initiatives including a new public compound database (PubChem); and technology development initiatives in chemical diversity, cheminformatics, assay development, screening instrumentation, and predictive ADMET. All research tools and results will be made publicly available without encumbrance. The small-molecule tools and technologies produced by the MLI will accelerate gene function determination, target validation, and downstream drug development.

1National Human Genome Research Institute and 2National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA. *Author for correspondence. E-mail: austinc{at}mail.nih.gov

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
An overview of the PubChem BioAssay resource.
Y. Wang, E. Bolton, S. Dracheva, K. Karapetyan, B. A. Shoemaker, T. O. Suzek, J. Wang, J. Xiao, J. Zhang, and S. H. Bryant (2009)
Nucleic Acids Res.
   Abstract »    Full Text »    PDF »
A survey of across-target bioactivity results of small molecules in PubChem.
L. Han, Y. Wang, and S. H. Bryant (2009)
Bioinformatics 25, 2251-2255
   Abstract »    Full Text »    PDF »
Chemical Approaches to Nuclear Receptors in Metabolism.
R. N. Margolis, D. D. Moore, T. M. Willson, and R. K. Guy (2009)
Science Signaling 2, mr5
   Abstract »    Full Text »    PDF »
Identification and Characterization of Novel Tissue-Nonspecific Alkaline Phosphatase Inhibitors with Diverse Modes of Action.
E. Sergienko, Y. Su, X. Chan, B. Brown, A. Hurder, S. Narisawa, and J. L. Millan (2009)
J Biomol Screen 14, 824-837
   Abstract »    PDF »
PubChem: a public information system for analyzing bioactivities of small molecules.
Y. Wang, J. Xiao, T. O. Suzek, J. Zhang, J. Wang, and S. H. Bryant (2009)
Nucleic Acids Res. 37, W623-W633
   Abstract »    Full Text »    PDF »
Potent, Selective and Cell Penetrant Inhibitors of SF-1 by Functional Ultra-High-Throughput Screening.
F. Madoux, X. Li, P. Chase, G. Zastrow, M. D. Cameron, J. J. Conkright, P. R. Griffin, S. Thacher, and P. Hodder (2008)
Mol. Pharmacol. 73, 1776-1784
   Abstract »    Full Text »    PDF »
Genome scale enzyme metabolite and drug target interaction predictions using the signature molecular descriptor.
J.-L. Faulon, M. Misra, S. Martin, K. Sale, and R. Sapra (2008)
Bioinformatics 24, 225-233
   Abstract »    Full Text »    PDF »
Comparison of Miniaturized Time-Resolved Fluorescence Resonance Energy Transfer and Enzyme-Coupled Luciferase High-Throughput Screening Assays to Discover Inhibitors of Rho-Kinase II (ROCK-II).
T. Schroter, D. Minond, A. Weiser, C. Dao, J. Habel, T. Spicer, P. Chase, P. Baillargeon, L. Scampavia, S. Schurer, et al. (2008)
J Biomol Screen 13, 17-28
   Abstract »    PDF »
The ToxCast Program for Prioritizing Toxicity Testing of Environmental Chemicals.
D. J. Dix, K. A. Houck, M. T. Martin, A. M. Richard, R. W. Setzer, and R. J. Kavlock (2007)
Toxicol. Sci. 95, 5-12
   Abstract »    Full Text »    PDF »
Systems Biology of Circadian Rhythms: An Outlook.
L. De Haro and S. Panda (2006)
J Biol Rhythms 21, 507-518
   Abstract »    PDF »
A New Mechanism of Methotrexate Action Revealed by Target Screening with Affinity Beads.
H. Uga, C. Kuramori, A. Ohta, Y. Tsuboi, H. Tanaka, M. Hatakeyama, Y. Yamaguchi, T. Takahashi, M. Kizaki, and H. Handa (2006)
Mol. Pharmacol. 70, 1832-1839
   Abstract »    Full Text »    PDF »
Roadmap or Roadkill: A Pharmacologist's Analysis of the NIH Molecular Libraries Initiative..
J. S. Lazo (2006)
Mol. Interv. 6, 240-243
   Full Text »    PDF »
Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries.
J. Inglese, D. S. Auld, A. Jadhav, R. L. Johnson, A. Simeonov, A. Yasgar, W. Zheng, and C. P. Austin (2006)
PNAS 103, 11473-11478
   Abstract »    Full Text »    PDF »
ChemMine. A Compound Mining Database for Chemical Genomics.
T. Girke, L.-C. Cheng, and N. Raikhel (2005)
Plant Physiology 138, 573-577
   Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)