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Science 12 November 2004:
Vol. 306. no. 5699, pp. 1124 - 1125
DOI: 10.1126/science.306.5699.1124
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News Focus

MOLECULAR BIOLOGY:
RNAi Shows Cracks in Its Armor

Jennifer Couzin

RNAi's tendency to influence genes and proteins that it's not designed to target is provoking questions and controversy, as scientists labor to solve the problem.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
RNAi-mediated gene silencing reveals involvement of Arabidopsis chromatin-related genes in Agrobacterium-mediated root transformation.
Y. M. Crane and S. B. Gelvin (2007)
PNAS 104, 15156-15161
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Adipocyte differentiation induced using nonspecific siRNA controls in cultured human mesenchymal stem cells.
Y. Xu, S.-H. Mirmalek-Sani, F. Lin, J. Zhang, and R. O.C. Oreffo (2007)
RNA 13, 1179-1183
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How Golden is Silence? Teaching Undergraduates the Power and Limits of RNA Interference.
N. H. Kuldell (2006)
CBE Life Sci Educ 5, 247-254
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RNA Interference Suppression of MUC1 Reduces the Growth Rate and Metastatic Phenotype of Human Pancreatic Cancer Cells..
H. Tsutsumida, B. J. Swanson, P. K. Singh, T. C. Caffrey, S. Kitajima, M. Goto, S. Yonezawa, and M. A. Hollingsworth (2006)
Clin. Cancer Res. 12, 2976-2987
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Science. ISSN 0036-8075 (print), 1095-9203 (online)