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Nodal proteins, members of the transforming growth factor–ß(TGFß) superfamily, have been identified as key endogenousmesoderm inducers in vertebrates. Precise control of Nodal signalingis essential for normal development of embryos. Here, we reportthat zebrafish dapper2 (dpr2) is expressed in mesoderm precursorsduring early embryogenesis and is positively regulated by Nodalsignals. In vivo functional studies in zebrafish suggest thatDpr2 suppresses mesoderm induction activities of Nodal signaling.Dpr2 is localized in late endosomes, binds to the TGFßreceptors ALK5 and ALK4, and accelerates lysosomal degradationof these receptors.
1 Laboratory of Developmental Biology, 2 Laboratory of Molecular Cell Biology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Protein Sciences Laboratory of the Ministry of Education (MOE), Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.
* These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail: mengam{at}mail.tsinghua.edu.cn (A.M.) and ygchen{at}mail.tsinghua.edu.cn (Y.-G.C.)
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