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What Can Progeroid Syndromes Tell Us About Human Aging?
David Kipling,1Terence Davis,1Elizabeth L. Ostler,2Richard G. A. Faragher2*
Human genetic diseases that resemble accelerated aging provideuseful models for gerontologists. They combine known single-genemutations with deficits in selected tissues that are reminiscentof changes seen during normal aging. Here, we describe recentprogress toward linking molecular and cellular changes withthe phenotype seen in two of these disorders. One in particular,Werner syndrome, provides evidence to support the hypothesisthat the senescence of somatic cells may be a causal agent ofnormal aging.
1 Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. 2 School of Pharmacy and Biomolecular Sciences, University of Brighton, Cockcroft Building, Brighton BN2 4GJ, UK.
* To whom correspondence should be addressed. E-mail: rgaf{at}brighton.ac.uk
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