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Hepatitis C virus (HCV) infects more than 180 million people worldwide and can lead to liver failure or liver cancer later in life. As Parham discusses in his thought-provoking Perspective, a step toward understanding how the human immune system resolves HCV infection and to developing a vaccine has been made with the finding that infected individuals of a particular genotype more readily resolve HCV infection than infected individuals of other genotypes (Khakoo et al.).
The author is in the Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. E-mail: peropa{at}stanford.edu
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In Science Magazine
REPORTS
Salim I. Khakoo, Chloe L. Thio, Maureen P. Martin, Collin R. Brooks, Xiaojiang Gao, Jacquie Astemborski, Jie Cheng, James J. Goedert, David Vlahov, Margaret Hilgartner, Steven Cox, Ann-Margeret Little, Graeme J. Alexander, Matthew E. Cramp, Stephen J. O'Brien, William M. C. Rosenberg, David L. Thomas, and Mary Carrington (6 August 2004) Science305 (5685), 872.
[DOI: 10.1126/science.1097670] |Abstract »|Full Text »|PDF »|Supporting Online Material »
A Single Polymorphism Disrupts the Killer Ig-Like Receptor 2DL2/2DL3 D1 Domain.
C. J. VandenBussche, S. Dakshanamurthy, P. E. Posch, and C. K. Hurley (2006)
J. Immunol.
177, 5347-5357
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Natural Killer Receptors on CD8 T Cells and Natural Killer Cells from Different HLA-C Phenotypes in Melanoma Patients..
J. A. Campillo, J. A. Martinez-Escribano, M. R. Moya-Quiles, L. A. Marin, M. Muro, N. Guerra, A. Parrado, M. Campos, J. F. Frias, A. Minguela, et al. (2006)
Clin. Cancer Res.
12, 4822-4831
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Killer Cell Ig-Like Receptor-Dependent Signaling by Ig-Like Transcript 2 (ILT2/CD85j/LILRB1/LIR-1).
