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Science 11 June 2004:
Vol. 304. no. 5677, pp. 1607 - 1609
DOI: 10.1126/science.1099577
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Perspectives

DEVELOPMENTAL BIOLOGY:
A Linker Histone Restricts Muscle Development

Lisa Cirillo and Ken Zaret

Much chromatin research has centered on modifications to the core histones that regulate gene expression. In their Perspective, Cirillo and Zaret discuss new findings that highlight a fifth type of histone, the linker histone H1, which is now shown to work with the Msx1 homeodomain protein to regulate the differentiation of muscle progenitor cells (Lee et al.).

L. Cirillo is in the Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA. K. Zaret is in the Cell and Developmental Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos.
X. Tan, J. Rotllant, H. Li, P. De Deyne, and S. J. Du (2006)
PNAS 103, 2713-2718
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Science. ISSN 0036-8075 (print), 1095-9203 (online)