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Science 4 June 2004:
Vol. 304. no. 5676, pp. 1455 - 1456
DOI: 10.1126/science.1099534
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Perspectives

NEUROSCIENCE:
Crossing the Midline

C. Geoffrey Woods

How do axons in the developing central nervous system know when and how to cross the midline to reach their neuronal targets on the other side. In his Perspective, Woods discusses the latest finding that the Robo3 receptor expressed by the growing axon tip releases inhibition of the chemoattractant Netrin, resulting in attraction of the axon tip to the midline (Jen et al.). Once the axon tip has crossed the midline, decreased expression of the Robo3 receptor ensures that the tip does not recross the midline.

The author is a Wellcome Trust Fellow and in the Molecular Medicine Unit, School of Medicine, University of Leeds, LS9 7TF, UK. E-mail: msjcgw{at}leeds.ac.uk

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Minireview: Recent Progress in Gonadotropin-Releasing Hormone Neuronal Migration.
S. A. Tobet and G. A. Schwarting (2006)
Endocrinology 147, 1159-1165
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Attraction or Repulsion: A Matter of Individual Taste?.
A. Wells and L. Lillien (2004)
Sci. STKE 2004, pe47
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)