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Heidi G. Parker,1,2,3Lisa V. Kim,1,2,4Nathan B. Sutter,1,2Scott Carlson,1Travis D. Lorentzen,1,2Tiffany B. Malek,1,3Gary S. Johnson,5Hawkins B. DeFrance,1,2Elaine A. Ostrander,1,2,3,4*Leonid Kruglyak1,3,4,6
We used molecular markers to study genetic relationships ina diverse collection of 85 domestic dog breeds. Differencesamong breeds accounted for 30% of genetic variation. Microsatellitegenotypes were used to correctly assign 99% of individual dogsto breeds. Phylogenetic analysis separated several breeds withancient origins from the remaining breeds with modern Europeanorigins. We identified four genetic clusters, which predominantlycontained breeds with similar geographic origin, morphology,or role in human activities. These results provide a geneticclassification of dog breeds and will aid studies of the geneticsof phenotypic breed differences.
1 Division of Human Biology, Fred Hutchinson Cancer Research Center, Post Office Box 19024, 1100 Fairview Avenue North, D4-100, Seattle, WA 98109–1024, USA. 2 Division of Clinical Research, Fred Hutchinson Cancer Research Center, Post Office Box 19024, 1100 Fairview Avenue North, D4-100, Seattle, WA 98109–1024, USA. 3 Molecular and Cellular Biology Program, University of Washington, Box 357275, Seattle, WA 98195–7275, USA. 4 Department of Genome Sciences, University of Washington, Box 351800, Seattle, WA 98195–7275, USA. 5 Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA. 6 Howard Hughes Medical Institute, 1100 Fairview Avenue North, D4-100, Seattle, WA 98109–1024, USA.
* To whom correspondence should be addressed. E-mail: eostrand{at}fhcrc.org
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