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BIOMEDICINE: Do Airborne Particles Induce Heritable Mutations?
Jonathan M. Samet, David M. DeMarini, Heinrich V. Malling
Air pollution is associated with an increased risk of lung cancer and has other adverse health effects. In their Perspective, Samet, DeMarini, and Malling discuss new findings (Somers et al.) showing that particulate air pollution can induce presumptive mutations in the germline cells of male mice that can be passed on to the next generation. The germline mutation rate was reduced by about 50% if the mice were exposed to air cleansed of particulate matter by passage through a HEPA filter.
J. M. Samet is in the Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA. D. M. DeMarini is at the U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. H. V. Malling is at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. E-mail: jsamet{at}jhsph.edu
Long-Term Effects of a Standardized Complex Mixture of Urban Dust Particulate on the Metabolic Activation of Carcinogenic Polycyclic Aromatic Hydrocarbons in Human Cells in Culture.
T. Musafia-Jeknic, B. Mahadevan, C. Pereira, and W. M. Baird (2005)
Toxicol. Sci.
88, 358-366
|Abstract »|Full Text »|PDF »
Air pollution and cancer: biomarker studies in human populations.
Relation between Ambient Air Quality and Selected Birth Defects, Seven County Study, Texas, 1997-2000.
S. M. Gilboa, P. Mendola, A. F. Olshan, P. H. Langlois, D. A. Savitz, D. Loomis, A. H. Herring, and D. E. Fixler (2005)
Am. J. Epidemiol.
162, 238-252
|Abstract »|Full Text »|PDF »
Altered Gene Expression Patterns in MCF-7 Cells Induced by the Urban Dust Particulate Complex Mixture Standard Reference Material 1649a.
B. Mahadevan, C. Keshava, T. Musafia-Jeknic, A. Pecaj, A. Weston, and W. M. Baird (2005)
Cancer Res.
65, 1251-1258
|Abstract »|Full Text »|PDF »
Particulate Air Pollution Causes Mutations in Germ Line.
(2004)
Journal Watch (General)
2004, 6
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