Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 9 April 2004:
Vol. 304. no. 5668, pp. 248 - 253
DOI: 10.1126/science.1094717
Prev | Table of Contents | Next

Review

Intracellular Parasite Invasion Strategies

L. D. Sibley

Intracellular parasites use various strategies to invade cells and to subvert cellular signaling pathways and, thus, to gain a foothold against host defenses. Efficient cell entry, ability to exploit intracellular niches, and persistence make these parasites treacherous pathogens. Most intracellular parasites gain entry via host-mediated processes, but apicomplexans use a system of adhesion-based motility called "gliding" to actively penetrate host cells. Actin polymerization–dependent motility facilitates parasite migration across cellular barriers, enables dissemination within tissues, and powers invasion of host cells. Efficient invasion has brought widespread success to this group, which includes Toxoplasma, Plasmodium, and Cryptosporidium.

Department of Molecular Microbiology, Center for Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.

E-mail: sibley{at}borcim.wustl.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inhibiting Plasmodium falciparum growth and heme detoxification pathway using heme-binding DNA aptamers.
J. C. Niles, J. L. DeRisi, and M. A. Marletta (2009)
PNAS 106, 13266-13271
   Abstract »    Full Text »    PDF »
Forward Genetics in Toxoplasma gondii Reveals a Family of Rhoptry Kinases That Mediates Pathogenesis.
L. D. Sibley, W. Qiu, S. Fentress, S. J. Taylor, A. Khan, and R. Hui (2009)
Eukaryot. Cell 8, 1085-1093
   Full Text »    PDF »
The origins of apicomplexan sequence innovation.
J. Wasmuth, J. Daub, J. M. Peregrin-Alvarez, C. A.M. Finney, and J. Parkinson (2009)
Genome Res. 19, 1202-1213
   Abstract »    Full Text »    PDF »
The Toxoplasma gondii-Shuttling Function of Dendritic Cells Is Linked to the Parasite Genotype.
H. Lambert, P. P. Vutova, W. C. Adams, K. Lore, and A. Barragan (2009)
Infect. Immun. 77, 1679-1688
   Abstract »    Full Text »    PDF »
Polymorphic Mucin Antigens CpMuc4 and CpMuc5 Are Integral to Cryptosporidium parvum Infection In Vitro.
R. M. O'Connor, P. B. Burns, T. Ha-Ngoc, K. Scarpato, W. Khan, G. Kang, and H. Ward (2009)
Eukaryot. Cell 8, 461-469
   Abstract »    Full Text »    PDF »
A Novel Actin-Related Protein Is Associated with Daughter Cell Formation in Toxoplasma gondii.
J. L. Gordon, W. L. Beatty, and L. D. Sibley (2008)
Eukaryot. Cell 7, 1500-1512
   Abstract »    Full Text »    PDF »
A Novel Immunoprecipitation Strategy Identifies a Unique Functional Mimic of the Glial Cell Line-Derived Neurotrophic Factor Family Ligands in the Pathogen Trypanosoma cruzi.
B. Lu and M. PereiraPerrin (2008)
Infect. Immun. 76, 3530-3538
   Abstract »    Full Text »    PDF »
Host-Directed Drug Targeting of Factors Hijacked by Pathogens.
A. Schwegmann and F. Brombacher (2008)
Science Signaling 1, re8
   Abstract »    Full Text »    PDF »
Functional Characterization of a Redundant Plasmodium TRAP Family Invasin, TRAP-Like Protein, by Aldolase Binding and a Genetic Complementation Test.
K. Heiss, H. Nie, S. Kumar, T. M. Daly, L. W. Bergman, and K. Matuschewski (2008)
Eukaryot. Cell 7, 1062-1070
   Abstract »    Full Text »    PDF »
Invasion of human retinal vascular endothelial cells by Toxoplasma gondii tachyzoites.
D O Zamora, J T Rosenbaum, and J R Smith (2008)
Br J Ophthalmol 92, 852-855
   Abstract »    Full Text »    PDF »
Alveolins, a New Family of Cortical Proteins that Define the Protist Infrakingdom Alveolata.
S. B. Gould, W.-H. Tham, A. F. Cowman, G. I. McFadden, and R. F. Waller (2008)
Mol. Biol. Evol. 25, 1219-1230
   Abstract »    Full Text »    PDF »
Proteomics and Glycomics Analyses of N-Glycosylated Structures Involved in Toxoplasma gondii-Host Cell Interactions.
S. Fauquenoy, W. Morelle, A. Hovasse, A. Bednarczyk, C. Slomianny, C. Schaeffer, A. Van Dorsselaer, and S. Tomavo (2008)
Mol. Cell. Proteomics 7, 891-910
   Abstract »    Full Text »    PDF »
Microneme Rhomboid Protease TgROM1 Is Required for Efficient Intracellular Growth of Toxoplasma gondii.
F. Brossier, G. L. Starnes, W. L. Beatty, and L. D. Sibley (2008)
Eukaryot. Cell 7, 664-674
   Abstract »    Full Text »    PDF »
Chemical Attenuation of Plasmodium berghei Sporozoites Induces Sterile Immunity in Mice.
L. A. Purcell, S. K. Yanow, M. Lee, T. W. Spithill, and A. Rodriguez (2008)
Infect. Immun. 76, 1193-1199
   Abstract »    Full Text »    PDF »
Modulation of the Host Cell Proteome by the Intracellular Apicomplexan Parasite Toxoplasma gondii.
M. M. Nelson, A. R. Jones, J. C. Carmen, A. P. Sinai, R. Burchmore, and J. M. Wastling (2008)
Infect. Immun. 76, 828-844
   Abstract »    Full Text »    PDF »
Death Receptor Ligation or Exposure to Perforin Trigger Rapid Egress of the Intracellular Parasite Toxoplasma gondii.
E. K. Persson, A. M. Agnarson, H. Lambert, N. Hitziger, H. Yagita, B. J. Chambers, A. Barragan, and A. Grandien (2007)
J. Immunol. 179, 8357-8365
   Abstract »    Full Text »    PDF »
The Role of Inositol Acylation and Inositol Deacylation in the Toxoplasma gondii Glycosylphosphatidylinositol Biosynthetic Pathway.
T. K. Smith, J. Kimmel, N. Azzouz, H. Shams-Eldin, and R. T. Schwarz (2007)
J. Biol. Chem. 282, 32032-32042
   Abstract »    Full Text »    PDF »
Artemisinin Induces Calcium-Dependent Protein Secretion in the Protozoan Parasite Toxoplasma gondii.
K. Nagamune, W. L. Beatty, and L. D. Sibley (2007)
Eukaryot. Cell 6, 2147-2156
   Abstract »    Full Text »    PDF »
Enucleated L929 Cells Support Invasion, Differentiation, and Multiplication of Trypanosoma cruzi Parasites.
V. C. Coimbra, D. Yamamoto, K. G. Khusal, V. D. Atayde, M. C. Fernandes, R. A. Mortara, N. Yoshida, M. J. M. Alves, and M. Rabinovitch (2007)
Infect. Immun. 75, 3700-3706
   Abstract »    Full Text »    PDF »
Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite.
J. Bosch, C. A. Buscaglia, B. Krumm, B. P. Ingason, R. Lucas, C. Roach, T. Cardozo, V. Nussenzweig, and W. G. J. Hol (2007)
PNAS 104, 7015-7020
   Abstract »    Full Text »    PDF »
A Secreted Serine-Threonine Kinase Determines Virulence in the Eukaryotic Pathogen Toxoplasma gondii.
S. Taylor, A. Barragan, C. Su, B. Fux, S. J. Fentress, K. Tang, W. L. Beatty, H. E. Hajj, M. Jerome, M. S. Behnke, et al. (2006)
Science 314, 1776-1780
   Abstract »    Full Text »    PDF »
PbGC{beta} Is Essential for Plasmodium Ookinete Motility to Invade Midgut Cell and for Successful Completion of Parasite Life Cycle in Mosquitoes.
M. Hirai, M. Arai, S. Kawai, and H. Matsuoka (2006)
J. Biochem. 140, 747-757
   Abstract »    Full Text »    PDF »
Recruitment of CD63 to Cryptococcus neoformans phagosomes requires acidification.
K. Artavanis-Tsakonas, J. C. Love, H. L. Ploegh, and J. M. Vyas (2006)
PNAS 103, 15945-15950
   Abstract »    Full Text »    PDF »
Two Separate, Conserved Acidic Amino Acid Domains within the Toxoplasma gondii MIC2 Cytoplasmic Tail Are Required for Parasite Survival.
G. L. Starnes, T. J. Jewett, V. B. Carruthers, and L. D. Sibley (2006)
J. Biol. Chem. 281, 30745-30754
   Abstract »    Full Text »    PDF »
Membrane Topology and Transient Acylation of Toxoplasma gondii Glycosylphosphatidylinositols..
J. Kimmel, T. K. Smith, N. Azzouz, P. Gerold, F. Seeber, K. Lingelbach, J.-F. Dubremetz, and R. T. Schwarz (2006)
Eukaryot. Cell 5, 1420-1429
   Abstract »    Full Text »    PDF »
Bile Acids Enhance Invasiveness of Cryptosporidium spp. into Cultured Cells..
H. Feng, W. Nie, A. Sheoran, Q. Zhang, and S. Tzipori (2006)
Infect. Immun. 74, 3342-3346
   Abstract »    Full Text »    PDF »
A MORN-repeat protein is a dynamic component of the Toxoplasma gondii cell division apparatus.
M.-J. Gubbels, S. Vaishnava, N. Boot, J.-F. Dubremetz, and B. Striepen (2006)
J. Cell Sci. 119, 2236-2245
   Abstract »    Full Text »    PDF »
Signaling During Pathogen Infection.
S. Munter, M. Way, and F. Frischknecht (2006)
Sci. STKE 2006, re5
   Abstract »    Full Text »    PDF »
Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor.
J. Bosch, S. Turley, T. M. Daly, S. M. Bogh, M. L. Villasmil, C. Roach, N. Zhou, J. M. Morrisey, A. B. Vaidya, L. W. Bergman, et al. (2006)
PNAS 103, 4852-4857
   Abstract »    Full Text »    PDF »
Unusual Kinetic and Structural Properties Control Rapid Assembly and Turnover of Actin in the Parasite Toxoplasma gondii.
N. Sahoo, W. Beatty, J. Heuser, D. Sept, and L. D. Sibley (2006)
Mol. Biol. Cell 17, 895-906
   Abstract »    Full Text »    PDF »
The rat Toxo1 locus directs toxoplasmosis outcome and controls parasite proliferation and spreading by macrophage-dependent mechanisms.
P. Cavailles, V. Sergent, C. Bisanz, O. Papapietro, C. Colacios, M. Mas, J.-F. Subra, D. Lagrange, M. Calise, S. Appolinaire, et al. (2006)
PNAS 103, 744-749
   Abstract »    Full Text »    PDF »
Insight into a Conserved Lifestyle: Protein-Carbohydrate Adhesion Strategies of Vector-Borne Pathogens.
R. R. Dinglasan and M. Jacobs-Lorena (2005)
Infect. Immun. 73, 7797-7807
   Full Text »    PDF »
Differential Subcellular Localization of Members of the Toxoplasma gondii Small Heat Shock Protein Family.
N. de Miguel, P. C. Echeverria, and S. O. Angel (2005)
Eukaryot. Cell 4, 1990-1997
   Abstract »    Full Text »    PDF »
Gliding Motility Leads to Active Cellular Invasion by Cryptosporidium parvum Sporozoites.
D. M. Wetzel, J. Schmidt, M. S. Kuhlenschmidt, J. P. Dubey, and L. D. Sibley (2005)
Infect. Immun. 73, 5379-5387
   Abstract »    Full Text »    PDF »
A Plasmodium Actin-depolymerizing Factor That Binds Exclusively to Actin Monomers.
H. Schuler, A.-K. Mueller, and K. Matuschewski (2005)
Mol. Biol. Cell 16, 4013-4023
   Abstract »    Full Text »    PDF »
Plastid segregation and cell division in the apicomplexan parasite Sarcocystis neurona.
S. Vaishnava, D. P. Morrison, R. Y. Gaji, J. M. Murray, R. Entzeroth, D. K. Howe, and B. Striepen (2005)
J. Cell Sci. 118, 3397-3407
   Abstract »    Full Text »    PDF »
A malarial cysteine protease is necessary for Plasmodium sporozoite egress from oocysts.
A. S.I. Aly and K. Matuschewski (2005)
J. Exp. Med. 202, 225-230
   Abstract »    Full Text »    PDF »
Scaling of maximum net force output by motors used for locomotion.
J. H. Marden (2005)
J. Exp. Biol. 208, 1653-1664
   Abstract »    Full Text »    PDF »
Class I Major Histocompatibility Complex Presentation of Antigens That Escape from the Parasitophorous Vacuole of Toxoplasma gondii.
M.-J. Gubbels, B. Striepen, N. Shastri, M. Turkoz, and E. A. Robey (2005)
Infect. Immun. 73, 703-711
   Abstract »    Full Text »    PDF »
Apical Organelle Discharge by Cryptosporidium parvum Is Temperature, Cytoskeleton, and Intracellular Calcium Dependent and Required for Host Cell Invasion.
X.-M. Chen, S. P. O'Hara, B. Q. Huang, J. B. Nelson, J. J.-C. Lin, G. Zhu, H. D. Ward, and N. F. LaRusso (2004)
Infect. Immun. 72, 6806-6816
   Abstract »    Full Text »    PDF »
Immunolocalization of Actin in Paramecium Cells.
R. Kissmehl, I. M. Sehring, E. Wagner, and H. Plattner (2004)
J. Histochem. Cytochem. 52, 1543-1559
   Abstract »    Full Text »    PDF »
Video Views and Reviews: Creating a Thread with Respect to the Invasion of Animal Viruses.
C. Watters (2004)
CBE Life Sci Educ 3, 218-222
   Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)