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Science 9 April 2004:
Vol. 304. no. 5668, p. 167
DOI: 10.1126/science.304.5668.167o
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This Week in Science

The communication between different membrane-bounded compartments in the cell is brought about by vesicles. Vesicles are generated from a donor compartment and travel to an acceptor organelle, where they will dock and fuse. Kamena and Spang (p. 286) show that an active mechanism exists in the cell that prevents back fusion of newly formed vesicles with the donor membrane. This mechanism provides directionality to vesicular transport. In Saccharomyces cerevisiae, the TIP20 protein prevents the back fusion of endoplasmic reticulum (ER)-derived vesicles and could thus act as a discriminator between incoming and outgoing vesicles at the ER.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)