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Science 9 April 2004:
Vol. 304. no. 5668, p. 167
DOI: 10.1126/science.304.5668.167n
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Two completely sequenced fungal genomes were compared that are sufficiently conserved to allow reconstruction of syntenies, but are sufficiently diverged to find multiple levels of sequence alterations. Although there was evidence that Saccharomyces cerevisiae evolved by a whole genome duplication, the newly sequenced Ashbya gossypii appears to resemble the ancestor predating that duplication. Through comparisons of the two genomes, Dietrich et al. (p. 304) were able to infer the history of changes that led from the ancient sequence to the modern ones.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)