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Science 2 April 2004:
Vol. 304. no. 5667, pp. 60 - 62
DOI: 10.1126/science.1096809
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Perspectives

CELL BIOLOGY:
Telomere Wedding Ends in Divorce

Claus M. Azzalin and Joachim Lingner

The separation of sister chromatids during mitosis depends on dissociation of proteins called cohesins, which hold the sister chromatids together, prompted by a protease called separase. In their Perspective, Azzalin and Lingner discuss new research (Dynek and Smith) revealing an additional type of cohesion between the ends of sister-chromatid telomeres that requires a separate enzyme called tankyrase 1 for separation during anaphase.

The authors are at the Swiss Institute for Experimental Cancer Research (ISREC), CH-1066 Epalinges, Lausanne, Switzerland. E-mail: joachim.lingner{at}isrec.unil.ch

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Science. ISSN 0036-8075 (print), 1095-9203 (online)