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Science 12 March 2004:
Vol. 303. no. 5664, pp. 1624 - 1625
DOI: 10.1126/science.1096222
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Perspectives

IMMUNOLOGY:
Keeping the Gut Microflora at Bay

Jean-Pierre Kraehenbuhl and Max Corbett

The commensal microflora of the gut provide benefits to the host. They help to digest dietary carbohydrate and to maintain the appropriate balance among different microbial species so that the chance of gut colonization by pathogenic bacteria is reduced. In their Perspective, Kraehenbuhl and Corbett discuss new work (MacPherson and Uhr) that reveals how the host's mucosal immune response prevents commensal bacteria from straying beyond the gut mucosa where they might induce an unwanted systemic inflammatory immune response.

The authors are at the Swiss Institute for Experimental Cancer Research, CH1066 Epalinges, Switzerland. E-mail: jean-pierre.kraehenbuhl{at}isrec. unil.ch

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