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Science 27 February 2004:
Vol. 303. no. 5662, pp. 1307 - 1308
DOI: 10.1126/science.1095483
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Perspectives

MOLECULAR BIOLOGY:
When a Part Is as Good as the Whole

Pieter L. deHaseth and Timothy W. Nilsen

One of the biggest bacterial enzymes is RNA polymerase, which synthesizes all of the different types of RNA in bacteria. In their Perspective, deHaseth and Nilsen dissect new work (Young et al.) that identifies the minimal portion of Escherichia coli RNA polymerase that is capable of inducing promoter melting, a critical step in the initiation of RNA synthesis.

The authors are in the RNA Center and Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA. E-mail: pld2{at}po.cwru.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The -11A of promoter DNA and two conserved amino acids in the melting region of {sigma}70 both directly affect the rate limiting step in formation of the stable RNA polymerase-promoter complex, but they do not necessarily interact.
L. A. Schroeder, A.-J. Choi, and P. L. deHaseth (2007)
Nucleic Acids Res.
   Abstract »    Full Text »    PDF »
Positional Conservation of Clusters of Overlapping Promoter-Like Sequences in Enterobacterial Genomes.
A. M. Huerta, J. Collado-Vides, and M. P. Francino (2006)
Mol. Biol. Evol. 23, 997-1010
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)