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Science 27 February 2004:
Vol. 303. no. 5662, p. 1253
DOI: 10.1126/science.303.5662.1253k
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To begin to understand how tissue specificity is established and maintained, Odom et al. (p. 1378; see the Perspective by Kulkarni and Kahn) have looked at the genes regulated by the transcription factors HNF1alpha, HNF4alpha, and HNF6 in human hepatocytes and pancreatic islet cells. Microarray and immunoprecipitation analyses were used to determine that HNF4alpha binds to almost half of the actively transcribed genes. HNF6 was involved in regulatory motifs that have been associated with sensitivity to sustained inputs. Lack of these HNF transcriptional regulators can cause a type of diabetes, and thus an understanding of these circuits may help future treatment of this disease.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)