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Science 20 February 2004:
Vol. 303. no. 5661, p. 1101
DOI: 10.1126/science.303.5661.1101p
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This Week in Science

Two signaling pathways that control axon guidance are the cyclic nucleotide-protein kinase A (PKA) pathway and a pathway controlled by Plexin A, a guidance receptor that responds to the repulsive guidance cue Semaphorin 1-a. Terman and Kolodkin (p. 1204) have determined that a single protein, Nervy, links these two pathways in Drosophila neurons. Nervy is an A Kinase anchoring protein that binds to both PKA and to Plexin A. When not bound to PKA, Nervy antagonizes both axonal repulsion and Plexin A signaling.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)