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Science 23 January 2004:
Vol. 303. no. 5657, pp. 480 - 482
DOI: 10.1126/science.1093449
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Perspectives

BIOCHEMISTRY:
Mimicking Posttranslational Modifications of Proteins

Benjamin G. Davis

Strategies for the synthesis of pure posttranslationally modified proteins or their mimics (for example, glycosylation or prenylation) have been recently developed. In his Perspective, Davis discusses how these strategies are allowing the creation of useful biomolecular probes and how they may offer a potential route to new protein pharmaceuticals.

The author is in the Dyson Perrins Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3QY, UK. E-mail: ben.davis{at}chemistry.oxford.ac.uk

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