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Science 16 January 2004:
Vol. 303. no. 5656, pp. 320 - 322
DOI: 10.1126/science.1094664
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Perspectives

STRUCTURAL BIOLOGY:
Surprising News from the PCC

Bernhard Dobberstein and Irmgard Sinning

It is well established that a protein-conducting channel enables hydrophilic secretory proteins to be translocated across membranes and hydrophobic membrane proteins to be inserted into lipid bilayers. In their Perspective, Dobberstein and Sinning discuss a new structural study (published elsewhere) that reveals the molecular mechanism of protein translocation in bacteria and eukaryotes.

B. Dobberstein is at the Zentrum für Molekulare Biologie and I. Sinning is at the Biochemiezentrum, Universität Heidelberg, 69120 Heidelberg, Germany. E-mail: dobberstein{at}zmbh.uni-heidelberg.de

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A trans-membrane segment inside the ribosome exit tunnel triggers RAMP4 recruitment to the Sec61p translocase.
M. R. Pool (2009)
J. Cell Biol. 185, 889-902
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Active and passive displacement of transmembrane domains both occur during opsin biogenesis at the Sec61 translocon.
N. Ismail, S. G. Crawshaw, and S. High (2006)
J. Cell Sci. 119, 2826-2836
   Abstract »    Full Text »    PDF »


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