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Science 19 December 2003:
Vol. 302. no. 5653, pp. 2141 - 2144
DOI: 10.1126/science.1090100
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Reports

Genome-Wide Survey of Human Alternative Pre-mRNA Splicing with Exon Junction Microarrays

Jason M. Johnson,* John Castle, Philip Garrett-Engele, Zhengyan Kan, Patrick M. Loerch, Christopher D. Armour, Ralph Santos, Eric E. Schadt, Roland Stoughton, Daniel D. Shoemaker*

Alternative pre–messenger RNA (pre-mRNA) splicing plays important roles in development, physiology, and disease, and more than half of human genes are alternatively spliced. To understand the biological roles and regulation of alternative splicing across different tissues and stages of development, systematic methods are needed. Here, we demonstrate the use of microarrays to monitor splicing at every exon-exon junction in more than 10,000 multi-exon human genes in 52 tissues and cell lines. These genome-wide data provide experimental evidence and tissue distributions for thousands of known and novel alternative splicing events. Adding to previous studies, the results indicate that at least 74% of human multi-exon genes are alternatively spliced.

Rosetta Inpharmatics LLC, Merck & Co., Inc., 12040 115th Avenue N.E., Kirkland, WA 98034, USA.

* To whom correspondence should be addressed. E-mail: jason_johnson{at}merck.com (J.M.J.); shoemakd{at}stanfordalumni.org (D.D.S.)

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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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K. Iida, M. Shionyu, and Y. Suso (2008)
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   Abstract »    Full Text »    PDF »
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A. Ratti, C. Fallini, C. Colombrita, A. Pascale, U. Laforenza, A. Quattrone, and V. Silani (2008)
J. Biol. Chem. 283, 7531-7541
   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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C. Ansong, S. O. Purvine, J. N. Adkins, M. S. Lipton, and R. D. Smith (2008)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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N. Gromak, G. Talotti, N. J. Proudfoot, and F. Pagani (2008)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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G. Ohno, M. Hagiwara, and H. Kuroyanagi (2008)
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   Abstract »    Full Text »    PDF »
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M. Irimia, J. L. Rukov, D. Penny, J. Garcia-Fernandez, J. Vinther, and S. W. Roy (2008)
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   Abstract »    Full Text »    PDF »
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C. Ben-Dov, B. Hartmann, J. Lundgren, and J. Valcarcel (2008)
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   Abstract »    Full Text »    PDF »
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S. Stamm (2008)
J. Biol. Chem. 283, 1223-1227
   Abstract »    Full Text »    PDF »
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K. J. Hertel (2008)
J. Biol. Chem. 283, 1211-1215
   Abstract »    Full Text »    PDF »
X:Map: annotation and visualization of genome structure for Affymetrix exon array analysis.
T. Yates, M. J. Okoniewski, and C. J. Miller (2008)
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   Abstract »    Full Text »    PDF »
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O. Kikin, Z. Zappala, L. D'Antonio, and P. S. Bagga (2008)
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   Abstract »    Full Text »    PDF »
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F. Birzele, R. Kuffner, F. Meier, F. Oefinger, C. Potthast, and R. Zimmer (2008)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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H. Kuroyanagi, G. Ohno, S. Mitani, and M. Hagiwara (2007)
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   Abstract »    Full Text »    PDF »
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T. Revil, J. Toutant, L. Shkreta, D. Garneau, P. Cloutier, and B. Chabot (2007)
Mol. Cell. Biol. 27, 8431-8441
   Abstract »    Full Text »    PDF »
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J. Blechingberg, S. Lykke-Andersen, T. H. Jensen, A. L. Jorgensen, and A. L. Nielsen (2007)
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   Abstract »    Full Text »    PDF »
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C. He, Z. Zuo, H. Chen, L. Zhang, F. Zhou, H. Cheng, and R. Zhou (2007)
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   Abstract »    Full Text »    PDF »
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J. A. Calarco, Y. Xing, M. Caceres, J. P. Calarco, X. Xiao, Q. Pan, C. Lee, T. M. Preuss, and B. J. Blencowe (2007)
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V. Filippov, M. Filippova, and P. J. Duerksen-Hughes (2007)
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T. Kwan, D. Benovoy, C. Dias, S. Gurd, D. Serre, H. Zuzan, T. A. Clark, A. Schweitzer, M. K. Staples, H. Wang, et al. (2007)
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Y.-F. Cheung, Z. Kan, P. Garrett-Engele, I. Gall, H. Murdoch, G. S. Baillie, L. M. Camargo, J. M. Johnson, M. D. Houslay, and J. C. Castle (2007)
J. Pharmacol. Exp. Ther. 322, 600-609
   Abstract »    Full Text »    PDF »
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P. Lonning, S Knappskog, V Staalesen, R Chrisanthar, and J. Lillehaug (2007)
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