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Science 5 December 2003:
Vol. 302. no. 5651, pp. 1757 - 1760
DOI: 10.1126/science.1091422
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Reports

The Needle Length of Bacterial Injectisomes Is Determined by a Molecular Ruler

Laure Journet, Céline Agrain, Petr Broz, Guy R. Cornelis*

Size determination represents a fundamental requirement for multicomponent biological structures. Some pathogenic bacteria possess a weapon derived from the flagellum. Like the flagellum, this type-III secretion apparatus, called the injectisome, has a transmembrane basal body, but the external component is a needle-like structure instead of a hook and a filament. Here, we provide evidence that the length of this needle is determined by the size of a protein, YscP, acting as a molecular ruler.

Biozentrum, Universität Basel, 4056 Basel, Switzerland.

* To whom correspondence should be addressed: E-mail: guy.cornelis{at}unibas.ch

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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PNAS 103, 16490-16495
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J. Biol. Chem. 280, 42929-42937
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The V-Antigen of Yersinia Forms a Distinct Structure at the Tip of Injectisome Needles.
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M. Quinaud, J. Chabert, E. Faudry, E. Neumann, D. Lemaire, A. Pastor, S. Elsen, A. Dessen, and I. Attree (2005)
J. Biol. Chem. 280, 36293-36300
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Type III Secretion: More Systems Than You Think.
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J. Sha, L. Pillai, A. A. Fadl, C. L. Galindo, T. E. Erova, and A. K. Chopra (2005)
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Bacterial Injectisomes: Needle Length Does Matter.
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Process of Protein Transport by the Type III Secretion System.
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Rafts Can Trigger Contact-mediated Secretion of Bacterial Effectors via a Lipid-based Mechanism.
F. G. van der Goot, G. T. van Nhieu, A. Allaoui, P. Sansonetti, and F. Lafont (2004)
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