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Originally published in Science Express on 30 October 2003
Science 5 December 2003:
Vol. 302. no. 5651, pp. 1751 - 1754
DOI: 10.1126/science.1091109
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Reports

Regulation of Flowering Time by Histone Acetylation in Arabidopsis

Yuehui He, Scott D. Michaels, Richard M. Amasino*

The Arabidopsis autonomous floral-promotion pathway promotes flowering independently of the photoperiod and vernalization pathways by repressing FLOWERING LOCUS C (FLC), a MADS-boxtranscription factor that blocks the transition from vegetative to reproductive development. Here, we report that FLOWERING LOCUS D (FLD), one of sixgenes in the autonomous pathway, encodes a plant homolog of a protein found in histone deacetylase complexes in mammals. Lesions in FLD result in hyperacetylation of histones in FLC chromatin, up-regulation of FLC expression, and extremely delayed flowering. Thus, the autonomous pathway regulates flowering in part by histone deacetylation. However, not all autonomous-pathway mutants exhibit FLC hyperacetylation, indicating that multiple means exist by which this pathway represses FLC expression.

Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA.

* To whom correspondence should be addressed. E-mail: amasino{at}biochem.wisc.edu

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