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Science 5 December 2003:
Vol. 302. no. 5651, pp. 1690 - 1691
DOI: 10.1126/science.1092874
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Perspectives

CELL BIOLOGY:
Smurfing at the Leading Edge

Aron B. Jaffe and Alan Hall

Cell biologists are only now beginning to unravel how cells maintain their polarity and how this polarity contributes to cell migration. In their Perspective, Jaffe and Hall discuss new research (Wang et al.) describing how ubiquitination and degradation of Rho GTPase (which is an important regulator of the actin cytoskeleton) results in spatial restriction of Rho at the rear of the cell, an essential step in cellular migration.

The authors are at the MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, University College London, London WC1E 6BT, UK. E-mail: a.jaffe{at}ucl.ac.uk; alan.hall{at}ucl.ac.uk

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