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Science 21 November 2003:
Vol. 302. no. 5649, pp. 1340 - 1341
DOI: 10.1126/science.1092041
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Perspectives
Also see the archival list of Science's Compass: Enhanced Perspectives
CELL BIOLOGY:
Enhanced: Shrinking Gels Pull Cells
Alex Mogilner and George Oster
Since the days of van Leeuwenhoek in the 1600s, cell biologists have marveled at how cells crawl. Although much is understood about the contractile forces generated at the leading edge of the crawling cell, little is known about the retraction force at the rear of the cell. In their Perspective, Mogilner and Oster discuss new work (Miao et al.) in an in vitro system consisting of nematode sperm cell extracts that reveals how the retraction force is generated.
A. Mogilner is in the Department of Mathematics and Center for Genetics and Development, University of California, Davis, CA 95616, USA. E-mail: mogilner{at}math.ucdavis.edu G. Oster is in the Department of Molecular and Cellular Biology and Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720-3112, USA. E-mail: goster{at}nature.berkeley.edu
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- The role of filament-packing dynamics in powering amoeboid cell motility.
- L. Miao, O. Vanderlinde, J. Liu, R. P. Grant, A. Wouterse, K. Shimabukuro, A. Philipse, M. Stewart, and T. M. Roberts (2008)
PNAS
105, 5390-5395
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- Merotelic kinetochores in mammalian tissue cells.
- E.D Salmon, D Cimini, L.A Cameron, and J.G DeLuca (2005)
Phil Trans R Soc B
360, 553-568
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- The dynamic kinetochore-microtubule interface.
- H. Maiato, J. DeLuca, E. D. Salmon, and W. C. Earnshaw (2004)
J. Cell Sci.
117, 5461-5477
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