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Science 24 October 2003:
Vol. 302. no. 5645, pp. 654 - 659
DOI: 10.1126/science.1088063
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Reports

Immune Control of Tuberculosis by IFN-{gamma}-Inducible LRG-47

John D. MacMicking,1* Gregory A. Taylor,2,3 John D. McKinney1

Interferon-{gamma} (IFN-{gamma}) provides an essential component of immunity to tuberculosis by activating infected host macrophages to directly inhibit the replication of Mycobacterium tuberculosis (Mtb). IFN-{gamma}–inducible nitric oxide synthase 2 (NOS2) is considered a principal effector mechanism, although other pathways may also exist. Here, we identify one member of a newly emerging 47-kilodalton (p47) guanosine triphosphatase family, LRG-47, that acts independently of NOS2 to protect against disease. Mice lacking LRG-47 failed to control Mtb replication, unlike those missing the related p47 guanosine triphosphatases IRG-47 or IGTP. Defective bacterial killing in IFN-{gamma}–activated LRG-47–/– macrophages was associated with impaired maturation of Mtb-containing phagosomes, vesicles that otherwise recruited LRG-47 in wild-type cells. Thus, LRG-47 may serve as a critical vacuolar trafficking component used to dispose of intracellular pathogens like Mtb.

1 Laboratory of Infection Biology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
2 Department of Medicine, Department of Immunology, Division of Geriatrics, and Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC 27705, USA.
3 Geriatric Research, Education, and Clinical Center, Durham Veterans Administration Medical Center, Durham, NC 27705, USA.

* To whom correspondence should be addressed. E-mail: macmicj{at}mail.rockefeller.edu

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