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Science 24 October 2003:
Vol. 302. no. 5645, p. 529
DOI: 10.1126/science.302.5645.529m
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This Week in Science
Although memory CD8+ T cells that recognize certain viruses depend on the early support of their CD4+ helper T cell colleagues, they can protect from subsequent infection without the need of further assistance. One question is what happens in cases of chronic viral infections, such as with hepatitis C virus (HCV), where viremia is not adequately controlled. Using a chimpanzee HCV infection model, Grakoui et al. (p. 659) demonstrate that responsive memory CD8+ T cells can endure after depletion of helper CD4+ T cells prior to secondary infection with the virus. However, persisting escape mutants were detected several months after infection, suggesting that ongoing T cell help may be required to control chronic viral infections effectively.
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