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Science Signaling - Call For Papers

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Science 24 October 2003:
Vol. 302. no. 5645, p. 529
DOI: 10.1126/science.302.5645.529l
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This Week in Science

Many vertebrate organs develop morphological asymmetries during embryogenesis. A dramatic example is the digestive system, where the liver and pancreas occupy asymmetric positions and the intestine bends in complex patterns for packing into the abdominal cavity. Using zebrafish as a model, Horne-Badovinac et al. (p. 662) investigated how the embryo translates left-right asymmetries in gene expression into morphologic asymmetry in the gut. Gut looping appears to be driven by asymmetric migration of a tissue called the "lateral plate mesoderm," which displaces the developing intestine to the left.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)