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Science 24 October 2003:
Vol. 302. no. 5645, p. 529
DOI: 10.1126/science.302.5645.529k
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Despite the huge global rise in tuberculosis, protective immunity to the causative pathogen, Mycobacterium tuberculosis (Mtb), is measurable in most infected individuals. Critical in mediating this is the cytokine interferon-gamma (IFN-gamma), which activates a variety of immune-response genes, of which nitric oxide synthase 2 (NOS2) is considered pivotal. MacMicking et al. (p. 654) identified a protein, LRG-47, that can mediate protection from Mtb infection independently of NOS2. Macrophages from mice lacking LRG-47 produced bacteria-laden phagosomes that could not fuse with lysosomes and thus impeded the normal cellular pathway for destroying intracellular bacteria.

Figure 3
CREDIT: MACMICKING ET AL.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)