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Science 17 October 2003:
Vol. 302. no. 5644, pp. 406 - 407
DOI: 10.1126/science.1091172
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Perspectives

MEDICINE:
PPARs as Therapeutic Targets: Reverse Cardiology?

Jorge Plutzky

Formation of the atherosclerotic lesions that lead to myocardial infarction is determined in part by inflammatory responses such as the production of lipid-laden macrophages. In his Perspective, Plutzky highlights the parts played by PPAR nuclear receptors, especially PPAR-delta (Lee et al.), in the modulation of inflammatory responses and hence atherosclerosis.

The author is in the Department of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. E-mail: jplutzky{at}rics.bwh.harvard.edu

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