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Science 3 October 2003:
Vol. 302. no. 5642, pp. 63 - 72
DOI: 10.1126/science.1091867
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Policy Forum

MEDICINE:
The NIH Roadmap

Elias Zerhouni

The NIH Roadmap is a set of bold initiatives aimed at accelerating medical research. These initiatives will address challenges that no single NIH institute could tackle alone, but the agency as a whole must undertake. The Roadmap identifies the most compelling opportunities in three arenas: new pathways to discovery, research teams of the future, and reengineering the clinical research enterprise.

The author is the director of the National Institutes of Health, Bethesda, MD 20892, USA.

For more information, visit http://nihroadmap.nih.gov

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   Full Text »    PDF »
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   Full Text »    PDF »
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   Full Text »    PDF »
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   Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Full Text »    PDF »
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   Full Text »    PDF »
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