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Science 26 September 2003:
Vol. 301. no. 5641, pp. 1870 - 1874
DOI: 10.1126/science.1089662
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Review

Communication in Neuronal Networks

Simon B. Laughlin1 and Terrence J. Sejnowski2,3*

Brains perform with remarkable efficiency, are capable of prodigious computation, and are marvels of communication. We are beginning to understand some of the geometric, biophysical, and energy constraints that have governed the evolution of cortical networks. To operate efficiently within these constraints, nature has optimized the structure and function of cortical networks with design principles similar to those used in electronic networks. The brain also exploits the adaptability of biological systems to reconfigure in response to changing needs.

1 Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.
2 Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
3 Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.

* To whom correspondence should be addressed. E-mail: terry{at}salk.edu

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