Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 26 September 2003:
Vol. 301. no. 5641, pp. 1856 - 1857
DOI: 10.1126/science.1090613
Prev | Table of Contents | Next

Perspectives

IMMUNOLOGY:
Giving Credit Where Credit Is Due

Natalya V. Serbina and Eric G. Pamer

Dendritic cells in the skin, called Langerhans cells, are the obvious candidates for transporting antigen from the epidermis to the lymph nodes and for activating T cell defense. However, as Serbina and Pamer discuss in their Perspective, at least in the case of viral antigens, it seems that other dendritic cell subsets residing in the dermis are the most important players in T cell-mediated defense against viral infection of the skin.

The authors are in the Infectious Diseases Service and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. E-mail: serbinan{at}mskcc.org; pamere@mskcc.org

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity.
C. L. Bennett, E. van Rijn, S. Jung, K. Inaba, R. M. Steinman, M. L. Kapsenberg, and B. E. Clausen (2005)
J. Cell Biol. 169, 569-576
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)