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NEUROSCIENCE: From Molecules to Memory in the Cerebellum
David J. Linden
Neuroscientists have long sought to elucidate the molecular underpinnings of the memories needed to learn, for example, a motor task. In his Perspective, Linden discusses new work (Koekkoek et al.) suggesting that long-term depression in Purkinje cells mediated by protein kinase C signaling is responsible for motor memory in a task called associative eyelid conditioning.
The author is in the Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. E-mail: dlinden{at}jhmi.edu
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In Science Magazine
REPORTS
S. K. E. Koekkoek, H. C. Hulscher, B. R. Dortland, R. A. Hensbroek, Y. Elgersma, T. J. H. Ruigrok, and C. I. De Zeeuw (19 September 2003) Science301 (5640), 1736.
[DOI: 10.1126/science.1088383] |Abstract »|Full Text »|PDF »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Isoform specificity of protein kinase Cs in synaptic plasticity.
Isoform Specificity of PKC Translocation in Living Aplysia Sensory Neurons and a Role for Ca2+-Dependent PKC APL I in the Induction of Intermediate-Term Facilitation..
Y. Zhao, K. Leal, C. Abi-Farah, K. C. Martin, W. S. Sossin, and M. Klein (2006)
J. Neurosci.
26, 8847-8856
|Abstract »|Full Text »|PDF »
An NMDA Receptor/Nitric Oxide Cascade Is Involved in Cerebellar LTD But Is Not Localized to the Parallel Fiber Terminal.
Timing of Conditioned Eyeblink Responses Is Impaired in Cerebellar Patients.
M. Gerwig, K. Hajjar, A. Dimitrova, M. Maschke, F. P. Kolb, M. Frings, A. F. Thilmann, M. Forsting, H. C. Diener, and D. Timmann (2005)
J. Neurosci.
25, 3919-3931
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Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency.
M. Sausbier, H. Hu, C. Arntz, S. Feil, S. Kamm, H. Adelsberger, U. Sausbier, C. A. Sailer, R. Feil, F. Hofmann, et al. (2004)
PNAS
101, 9474-9478
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Comment on "Cerebellar LTD and Learning-Dependent Timing of Conditioned Eyelid Responses".
K. M. Christian, A. M. Poulos, D. G. Lavond, and R. F. Thompson (2004)
Science
304, 211b
|Full Text »|PDF »
Temporal Properties of Cerebellar-Dependent Memory Consolidation.
S. F. Cooke, P. J. E. Attwell, and C. H. Yeo (2004)
J. Neurosci.
24, 2934-2941
|Abstract »|Full Text »|PDF »
Reversing cerebellar long-term depression.
V. Lev-Ram, S. B. Mehta, D. Kleinfeld, and R. Y. Tsien (2003)
PNAS
100, 15989-15993
|Abstract »|Full Text »|PDF »
