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Science 15 August 2003:
Vol. 301. no. 5635, pp. 927 - 928
DOI: 10.1126/science.1088948
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Perspectives

GENETICS:
Modifying the Message

Joseph H. Nadeau

It has long been known that phenotypic variation involves a complex web of interactions with genetic background influencing the expression of genetic variants. In his Perspective, Nadeau describes new work (Buchner et al.) that identifies a modifier gene and determines how it acts to affect the severity of neuronal defects in medJ mice.

The author is in the Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA. E-mail: jhn4{at}cwru.edu

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