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Science 11 July 2003:
Vol. 301. no. 5630, pp. 229 - 232
DOI: 10.1126/science.1084204
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Reports

Neuronal Correlates of Goal-Based Motor Selection in the Prefrontal Cortex

Kenji Matsumoto,* Wataru Suzuki, Keiji Tanaka

Choosing an action that leads to a desired goal requires an understanding of the linkages between actions and their outcomes. We investigated neural mechanisms of such goal-based action selection. We trained monkeys on a task in which the relation between visual cues, action types, and reward conditions changed regularly, such that the monkeys selected their actions based on anticipated reward conditions. A significant number of neurons in the medial prefrontal cortex were activated, after cue presentation and before motor execution, only by particular action-reward combinations. This prefrontal activity is likely to underlie goal-based action selection.

Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

* To whom correspondence should be addressed. E-mail: matsumot{at}postman.riken.go.jp

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