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Science 27 June 2003:
Vol. 300. no. 5628, p. 2000
DOI: 10.1126/science.300.5628.2000m
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Gp130 is a shared signal-transducing receptor for a family of four-helix bundle cytokines including the pro-inflammatory cytokine interleukin-6 (IL-6). Signaling through the gp130 receptor is critical to the normal growth and differentiation of numerous tissue types. Boulanger et al. (p. 2101) have determined a 3.65 angstrom- resolution structure of a multicomponent receptor complex comprising human IL-6, the extracellular binding domains of human IL-6 -receptor, and the extracellular activation and binding domains of gp130. The hexamer assembles sequentially; a binary complex between IL-6R and IL-6 binds to gp130, and this step facilitates a cooperative transition to the signaling-competent hexamer.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)